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1

Container Closure Integrity Testing of Prefilled Syringes

Peláez, Sarah S., Mahler, Hanns-Christian, Matter, Anja, Koulov, Atanas, Singh, Satish K., Germershaus, Oliver, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Year:

2018

Language:

english

File:

PDF, 2.04 MB

english, 2018

2

Use of the permitted daily exposure (PDE) concept for contaminants of intravitreal (IVT) drugs in multipurpose manufacturing facilities

Barle, Ester Lovsin, Pfister, Thomas, Fux, Cornelia, Röthlisberger, Dieter, Jere, Dhananjay, Mahler, Hanns-Christian

Journal:

Regulatory Toxicology and Pharmacology

Year:

2018

Language:

english

File:

PDF, 495 KB

english, 2018

3

Grammaire expliquee du francais contemporain

Laeufer, Christiane, Mahler, Marguerite

Journal:

The Modern Language Journal

Year:

1994

Language:

english

File:

PDF, 792 KB

english, 1994

4

Current Challenges and Potential Opportunities for the Pharmaceutical Sciences to Make Global Impact: An FIP Perspective

Tucker, Geoffrey, DeSilva, Binodh, Dressman, Jennifer, Ito, Michiho, Kumamoto, Takuya, Mager, Don, Mahler, Hanns-Christian, Maitland-van der Zee, Anke H., Pauletti, Giovanni M., Sasaki, Hitoshi, Shah,

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 345 KB

english, 2016

5

Considerations for the Use of Polysorbates in Biopharmaceuticals

Jones, Michael T., Mahler, Hanns-Christian, Yadav, Sandeep, Bindra, Dilbir, Corvari, Vincent, Fesinmeyer, R. Matthew, Gupta, Kapil, Harmon, Alexander M., Hinds, Kenneth D., Koulov, Atanas, Liu, Wei, M

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 1.15 MB

english, 2018

6

Entropic regularization of continuous optimal transport problems

Clason, Christian, Lorenz, Dirk A., Mahler, Hinrich, Wirth, Benedikt

Journal:

Journal of Mathematical Analysis and Applications

Year:

2021

File:

PDF, 525 KB

2021

7

Measuring Tissue Back-Pressure -In VivoInjection Forces During Subcutaneous Injection

Allmendinger, Andrea, Mueller, Robert, Schwarb, Edward, Chipperfield, Mark, Huwyler, Joerg, Mahler, Hanns-Christian, Fischer, Stefan

Journal:

Pharmaceutical Research

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015

8

Particle Shedding from Peristaltic Pump Tubing in Biopharmaceutical Drug Product Manufacturing

Saller, Verena, Matilainen, Julia, Grauschopf, Ulla, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Friess, Wolfgang

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

9

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Leachables and Extractables: From Regulatory Expectations to Laboratory Assessment

Warne, Nicholas W., Mahler, Hanns-Christian

Year:

2018

Language:

english

File:

PDF, 260 KB

english, 2018

10

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Container Closure Integrity Testing of Primary Containers for Parenteral Products

Warne, Nicholas W., Mahler, Hanns-Christian

Year:

2018

Language:

english

File:

PDF, 913 KB

english, 2018

11

[Society of Petroleum Engineers SPE Europec featured at 80th EAGE Conference and Exhibition - Copenhagen, Denmark (2018-06-08)] SPE Europec featured at 80th EAGE Conference and Exhibition - Biopolymer Injection in Offshore Single-Well Test

Beeder, Janiche, Skarstad, Anita, Prasad, Dhruva, Todosijevic, Ana, Mahler, Eva, Fleck, Christian, Lehr, Florian

Language:

english

File:

PDF, 717 KB

english

12

Method to Predict Glass Vial Fogging in Lyophilized Drug Products

Langer, Carolin, Mahler, Hanns-Christian, Koulov, Atanas, Marti, Nicolas, Grigore, Cristina, Matter, Anja, Chalus, Pascal, Singh, Satish, Lemazurier, Thomas, Joerg, Susanne, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Year:

2019

Language:

english

File:

PDF, 1.64 MB

english, 2019

13

Stabilizing Polysorbate 20 and 80 Against Oxidative Degradation

Schmidt, Ariane, Koulov, Atanas, Huwyler, JÃ¶rg, Mahler, Hanns-Christian, Jahn, Michael

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 1.11 MB

2020

14

Evaluation of the immuno-stimulatory potential of stopper extractables and leachables by using dendritic cells as readout

Robert Mueller, Anette Karle, Anne Vogt, Harald Kropshofer, Alfred Ross, Karsten Maeder, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 399 KB

english, 2009

15

Assessment of net charge and protein–protein interactions of different monoclonal antibodies

Christian Lehermayr, Hanns-Christian Mahler, Karsten Mäder, Stefan Fischer

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 331 KB

english, 2011

16

Forced degradation of therapeutic proteins

Andrea Hawe, Michael Wiggenhorn, Marco van de Weert, Joerg H. O. Garbe, Hanns-christian Mahler, Wim Jiskoot

Journal:

Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 193 KB

english, 2012

17

FTIR and nDSC as Analytical Tools for High-Concentration Protein Formulations

Susanne Matheus, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 730 KB

english, 2006

18

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Comparison of Methods for Soluble Aggregate Detection and Size Characterization

Mahler, Hanns-Christian, Jiskoot, Wim

Year:

2012

Language:

english

File:

PDF, 270 KB

english, 2012

19

Analysis of Aggregates and Particles in Protein Pharmaceuticals (Mahler/Protein Aggregates Analysis) || Separation-Based Analytical Methods for Measuring Protein Aggregation

Mahler, Hanns-Christian, Jiskoot, Wim

Year:

2012

Language:

english

File:

PDF, 249 KB

english, 2012

20

Investigating factors leading to fogging of glass vials in lyophilized drug products

Abdul-Fattah, Ahmad M., Oeschger, Richard, Roehl, Holger, Bauer Dauphin, Isabelle, Worgull, Martin, Kallmeyer, Georg, Mahler, Hanns-Christian

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2013

Language:

english

File:

PDF, 2.22 MB

english, 2013

21

Synthesis of highly phenylene substituted p-phenylene oligomers from pyrylium salts

Mahler, Christian, Müller, Ute, Müller, Walter M., Enkelmann, Volker, Moon, Chulsoon, Brunklaus, Gunther, Zimmermann, Herbert, Höger, Sigurd

Journal:

Chemical Communications

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

22

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities

Ríos Quiroz, Anacelia, Québatte, Gabriela, Stump, Fabian, Finkler, Christof, Huwyler, Joerg, Schmidt, Roland, Mahler, Hanns-Christian, Koulov, Atanas V., Adler, Michael

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 885 KB

english, 2015

23

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests

Mathaes, Roman, Mahler, Hanns-Christian, Buettiker, Jean-Pierre, Roehl, Holger, Lam, Philippe, Brown, Helen, Luemkemann, Joerg, Adler, Michael, Huwyler, Joerg, Streubel, Alexander, Mohl, Silke

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2015

Language:

english

File:

PDF, 2.92 MB

english, 2015

24

Freeze-Drying of l-Arginine/Sucrose-Based Protein Formulations, Part 2: Optimization of Formulation Design and Freeze-Drying Process Conditions for an l-Arginine Chloride-Based Protein Formulation System

Stärtzel, Peter, Gieseler, Henning, Gieseler, Margit, Abdul-Fattah, Ahmad M., Adler, Michael, Mahler, Hanns-Christian, Goldbach, Pierre

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 797 KB

english, 2015

25

Optimization of the bake-on siliconization of cartridges. Part I: Optimization of the spray-on parameters

Funke, Stefanie, Matilainen, Julia, Nalenz, Heiko, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Friess, Wolfgang

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2016

Language:

english

File:

PDF, 747 KB

english, 2016

26

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator

Folzer, Emilien, Khan, Tarik A., Schmidt, Roland, Finkler, Christof, Huwyler, Jörg, Mahler, Hanns-Christian, Koulov, Atanas V.

Journal:

Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 342 KB

english, 2015

27

Optimization of the bake-on siliconization of cartridges. Part II: Investigations into burn-in time and temperature

Funke, Stefanie, Matilainen, Julia, Nalenz, Heiko, Bechtold-Peters, Karoline, Mahler, Hanns-Christian, Vetter, Florian, Müller, Christoph, Bracher, Franz, Friess, Wolfgang

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2016

Language:

english

File:

PDF, 1.95 MB

english, 2016

28

Statement of the German Contact Dermatitis Research Group (DKG) and the German Dermatological Society (DDG) on liability issues associated with patch testing using a patient's own materials

Mahler, Vera, Dickel, Heinrich, Diepgen, Thomas Ludwig, Hillen, Uwe, Geier, Johannes, Kaufmann, Roland, Kreft, Burkhard, Schnuch, Axel, Szliska, Christiane, Bender, Albrecht

Journal:

JDDG: Journal der Deutschen Dermatologischen Gesellschaft

Year:

2016

Language:

english

File:

PDF, 105 KB

english, 2016

29

No immediate effect on urodynamic parameters during transcutaneous electrical nerve stimulation (TENS) in children with overactive bladder and daytime incontinence-A randomized, double-blind, placebo-controlled study

Borch, Luise, Rittig, Soeren, Kamperis, Konstantinos, Mahler, Birgitte, Djurhuus, Jens Christian, Hagstroem, Soeren

Journal:

Neurourology and Urodynamics

Year:

2016

Language:

english

File:

PDF, 483 KB

english, 2016

30

Developing protein therapeutics

Mahler, Hanns-Christian

Journal:

Journal of Pharmacy and Pharmacology

Year:

2018

Language:

english

File:

PDF, 168 KB

english, 2018

31

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials

Ditter, Dominique, Mahler, Hanns-Christian, Gohlke, Linus, Nieto, Alejandra, Roehl, Holger, Huwyler, Joerg, Wahl, Michael, Allmendinger, Andrea

Journal:

Pharmaceutical Research

Year:

2018

Language:

english

File:

PDF, 18.40 MB

english, 2018

32

[AAPS Advances in the Pharmaceutical Sciences Series] Challenges in Protein Product Development Volume 38 || Development of Prefilled Syringe Combination Products for Biologics

Warne, Nicholas W., Mahler, Hanns-Christian

Year:

2018

Language:

english

File:

PDF, 591 KB

english, 2018

33

Standardisierte Nachbesprechung von Zwangsmaßnahmen auf psychiatrischen Akutstationen: Ergebnisse einer Pilotstudie

Wullschleger, Alexandre, Vandamme, Angelika, Ried, Jennifer, Pluta, Mara, Montag, Christiane, Mahler, Lieselotte

Journal:

Psychiatrische Praxis

Year:

2018

Language:

german

File:

PDF, 374 KB

german, 2018

34

Particle Analysis of Biotherapeutics in Human Serum using Machine Learning

Schuster, Joachim, Koulov, Atanas, Mahler, Hanns-Christian, Joerg, Susanne, Huwyler, Joerg, Schleicher, Kai, Detampel, Pascal, Mathaes, Roman

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 2.55 MB

2020

35

Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population

Hans Jörgen Grabe, Christian Schwahn, Katja Appel, Jessie Mahler, Andrea Schulz, Carsten Spitzer, Kristin Fenske, Sven Barnow, Michael Lucht, Harald Jürgen Freyberger, Ulrich John, Alexander Teumer, H

Journal:

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Year:

2010

Language:

english

File:

PDF, 331 KB

english, 2010

36

Behaviour of polysorbate 20 during dialysis, concentration and filtration using membrane separation techniques

Hanns-Christian Mahler, Miriam Printz, Robert Kopf, Rudolf Schuller, Robert Müller

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 208 KB

english, 2008

37

Shaken, not stirred: Mechanical stress testing of an IgG1 antibody

Sylvia Kiese, Astrid Papppenberger, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Year:

2008

Language:

english

File:

PDF, 503 KB

english, 2008

38

Liquid high concentration IgG1 antibody formulations by precipitation

Susanne Matheus, Wolfgang Friess, Daniel Schwartz, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 312 KB

english, 2009

39

Protein aggregation: Pathways, induction factors and analysis

Hanns-Christian Mahler, Wolfgang Friess, Ulla Grauschopf, Sylvia Kiese

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 282 KB

english, 2009

40

Surface activity of a monoclonal antibody

Hanns-Christian Mahler, Frank Senner, Karsten Maeder, Robert Mueller

Journal:

Journal of Pharmaceutical Sciences

Year:

2009

Language:

english

File:

PDF, 189 KB

english, 2009

41

Equilibrium studies of protein aggregates and homogeneous nucleation in protein formulation

Sylvia Kiese, Astrid Pappenberger, Wolfgang Friess, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 335 KB

english, 2010

42

Adsorption behavior of a surfactant and a monoclonal antibody to sterilizing-grade filters

Hanns-Christian Mahler, Franziska Huber, Ravuri S.K. Kishore, Jürgen Reindl, Peter Rückert, Robert Müller

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 146 KB

english, 2010

43

An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics

Satish K. Singh, Nataliya Afonina, Michel Awwad, Karoline Bechtold-Peters, Jeffrey T. Blue, Danny Chou, Mary Cromwell, Hans-Juergen Krause, Hanns-Christian Mahler, Brian K. Meyer, Linda Narhi, Doug P.

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

44

Adsorption of monoclonal antibodies to glass microparticles

Matthew Hoehne, Fauna Samuel, Aichun Dong, Christine Wurth, Hanns-Christian Mahler, John F. Carpenter, Theodore W. Randolph

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 311 KB

english, 2011

45

Degradation of polysorbates 20 and 80: Studies on thermal autoxidation and hydrolysis

Ravuri S. K. Kishore, Astrid Pappenberger, Isabelle Bauer Dauphin, Alfred Ross, Beatrice Buergi, Andreas Staempfli, Hanns-Christian Mahler

Journal:

Journal of Pharmaceutical Sciences

Year:

2011

Language:

english

File:

PDF, 358 KB

english, 2011

46

Blue-Green Light Emitting Poly(phenylenevinylene) Derivatives as Candidates for Polymer LEDs: Synthesis and Characterization

A. Kai Mahler, Horst Schlick, Robert Saf, Franz Stelzer, Farideh Meghdadi, Alexander Pogantsch, Günther Leising, Kai-Christian Möller, Jürgen O. Besenhard

Journal:

Macromolecular Chemistry and Physics

Year:

2004

Language:

english

File:

PDF, 184 KB

english, 2004

47

Freeze drying of human serum albumin (HSA) nanoparticles with different excipients

Marion G. Anhorn, Hanns-Christian Mahler, Klaus Langer

Journal:

International Journal of Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 666 KB

english, 2008

48

Component-Resolved Diagnosis (CRD) of Type I Allergy with Recombinant Grass and Tree Pollen Allergens by Skin Testing

Heiss, Susanne, Mahler, Vera, Steiner, Renate, Spitzauer, Susanne, Schweiger, Christian, Kraft, Dietrich, Valenta, Rudolf

Journal:

The Journal of Investigative Dermatology

Year:

1999

Language:

english

File:

PDF, 276 KB

english, 1999

49

Singlet oxygen affects the activity of the thylakoid ATP synthase and has a strong impact on its γ subunit

Hanno Mahler, Petra Wuennenberg, Monica Linder, Dominika Przybyla, Christian Zoerb, Frank Landgraf, Christoph Forreiter

Journal:

Year:

2007

Language:

english

File:

PDF, 511 KB

english, 2007

50

A Critical Evaluation ofTm(FTIR)Measurements of High-Concentration IgG1Antibody Formulations as a Formulation Development Tool

Susanne Matheus, Hanns-Christian Mahler, Wolfgang Friess

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 331 KB

english, 2006

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